Endothelin-1 and interleukin-8 in high altitude pulmonary oedema.

Unravelling the Pathogenesis of Severe COVID-19 Pneumonia: Are There Possible Insights From High Altitude?

Exaggerated endothelin release in high-altitude pulmonary edema.

BACKGROUND Exaggerated pulmonary hypertension is thought to play an important part in the pathogenesis of high-altitude pulmonary edema (HAPE). Endothelin-1 is a potent pulmonary vasoconstrictor peptide that also augments microvascular permeability. METHODS AND RESULTS We measured endothelin-1 plasma levels and pulmonary artery pressure in 16 mountaineers prone to HAPE and in 16 mountaineers ...

Cytokines in bronchoalveolar lavage fluid in patients with high altitude pulmonary oedema at moderate altitude in Japan.

BACKGROUND The precise mechanism of high altitude pulmonary oedema (HAPE) remains unclear. The purpose of this study was to evaluate the role of cytokines and P-selectin in the development of HAPE which occurred at moderate altitude in Japan. METHODS The following cellular and biochemical markers and chemotactic cytokines were measured in the bronchoalveolar (BAL) fluid from four patients wit...

Time course of asymptomatic interstitial pulmonary oedema at high altitude.

The time course of asymptomatic pulmonary oedema during high-altitude exposure and its potential relationship with changes in cardiac function remain to clarify. Eleven volunteers were rapidly exposed to 4350m during a 4-day period. Each subject received clinical examination and thoracic ultrasonography to assess ultrasound lung comets (USLC) on day 1, 2 and 3 after arrival. Echocardiography wa...

Supplemental L-arginine Modulates Developmental Pulmonary Hypertension in Broiler Chickens Fed Reduced-Protein Diets and Reared at High Altitude

This experiment was conducted to evaluate the effects of supplemental L-arginine (ARG) in reduced-protein diets on cardiopulmonary performance and intestinal morphology in the broilers reared at high altitude. A total of 156 day-old male broilers were randomly assigned to 3 treatments and 4 replicates of 13 chicks and reared up to 42 days of age. Treatment groups were designed as a normal-prote...